WebNational Center for Biotechnology Information WebThe synovium is a mesenchymal tissue composed mainly of fibroblasts with a lining and sublining that surrounds the joints. In rheumatoid arthritis (RA), the synovial tissue …
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WebNov 18, 2008 · The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage ( Lorenzo et al., 1998 ), increases in early osteoarthrosis cartilage. By RT-PCR using human articular cartilage RNA and degenerate primers based on the amino acid sequence of CILP, and by screening a … WebApr 15, 2024 · Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure JACC Basic Transl Sci. 2024 Apr 15 ... All 3 encoded …
WebMay 30, 2024 · Breast cancer (BC) is the second leading cause of brain metastases (BM), with high morbidity and mortality. The aim of our study was to explore the effect of the cartilage intermediate layer protein (CILP) on breast cancer brain metastases (BCBM). Using a weighted gene coexpression network analysis (WGCNA) in GSE100534 and … WebOct 13, 2024 · After angiotensin II treatment, Fibroblast-Cilp develops as the most abundant fibroblast subpopulation and the predominant fibrogenic cell type. Mapping intercellular communication networks within the heart, we identified key intercellular …
WebA total of 14 cell subtypes were obtained (Figure 1(b)), in which activated CFs expressed high levels of profibrotic factors such as Postn, Sparc, and Cilp [29][30] [31]. Ly6a + CFs expressed high ... WebOct 26, 2024 · The lack of specificity of FSP-1 and the limitations of fibroblast markers. In the early years of cell-specific in vivo targeting, FSP-1/S100A4 was used as a fibroblast-specific marker in many high-profile studies. 7 However, over the last 10 years, extensive evidence has emerged challenging its specificity. In addition to its expression by …
WebAug 7, 2024 · Based on established markers for fibroblast and mural cell types in the brain vasculature 11,13, we first assigned preliminary annotations of fibroblast and mural cell archetypes in the combined ...
WebJan 28, 2024 · The high frequency of fibroblasts expressing all three genes, especially in neonatal fibroblasts, suggests that individual fibroblasts are co-expressing multiple key … crypto mint meaningWebJul 8, 2016 · Multicellular 3D culture and interaction with stromal components are considered essential elements in establishing a ‘more clinically relevant’ tumor model. Matrix-embedded 3D cultures using a microfluidic chip platform can recapitulate the microscale interaction within tumor microenvironments. As a major component of tumor microenvironment, … crypto mining worth it 2023WebJun 21, 2024 · Genes encoding ECM proteins were associated with aCSC-1 (Eln, Wisp2), aCSC-2 (Thbs4, Cilp), and aCSC-4 (Smoc2, Sparcl1). Cell populations with similar gene signatures were recently termed activated … cryptostar yahooWebMay 17, 2024 · Thus, in addition to the well-studied myofibroblast, it seems that CFs are more phenotypically dynamic than previously thought. E.g., two new fibroblast sub … cryptostakersWebMay 17, 2024 · Thus, in addition to the well-studied myofibroblast, it seems that CFs are more phenotypically dynamic than previously thought. E.g., two new fibroblast sub-populations, Cilp-positive and Thbs4-positive, were identified in angiotensin II (Ang II)-infused mouse hearts where Cilp-positive were the cryptosteel discount codeWebApr 20, 2024 · The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that expand following injury and play a reparative role but also contribute to maladaptive fibrotic remodeling. Following myocardial infarction, cardiac fibroblasts undergo dynamic phenotypic transitions, contributing to the regulation of inflammatory, … crypto mirWebMar 12, 2024 · All three fibroblast populations were PDGFRα+/CD34 + but were distinct in their expression of Ngfr/Spon2/Angptl7 (F1), Cxcl14/Smoc2/Rgs2 (F2), and Clec3b/Col14a1/Mmp3 (F3), with … crypto minted meaning