Dek c terminal domain containing protein
WebMar 20, 2024 · DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes... WebThe START domain is always located in the C-terminus of the protein. It is a module of about 210 residues that binds lipids, including sterols. Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, …
Dek c terminal domain containing protein
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WebApr 1, 2005 · The 375-residue human protein DEK is a proto-oncogene protein that is associated with chromatin [1]. DEK was first discovered in patients with a subtype of acute myelogenous leukemia (AML) as a fusion product in which its C-terminal 26 amino acids are replaced by the N-terminal two-thirds of the nucleoporin CAN [2]. WebThe DEK-C domain was first detected in the C-terminal region of the chromatin-associated protein DEK. The DEK-C domain is able to bind DNA and induce protein-protein …
WebNational Center for Biotechnology Information Web112-267: 3.33e-104: RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1
WebMar 28, 2024 · DEK domain-containing protein (DEK) is an abundant DNA-binding protein that was originally identified as a DEK–NUP213 fusion protein in human acute … WebFeb 1, 2008 · The 375-residue, 45 kDa DEK protein was first identified in patients with a subtype of AML as a fusion product in which its C-terminal 26 amino acids are replaced by the C-terminal two-thirds of the nucleoporin CAN (von Lindern et al. 1992).Overexpression of DEK has been found in a number of aggressive human tumors including acute …
WebFERM domains are trilobed, typically N-terminal domains (Chishti et al., 1998). They are commonly found in proteins that bind cytoplasmic regions of transmembrane proteins and often act as linkers between the cytoskeleton and plasma membrane.
WebDEK was originally described as a proto-oncogene protein and is now known to be a major component of metazoan chromatin. DEK is able to modify the structure of DNA by introducing supercoils. In order to find interaction partners and functional domains of DEK, we performed yeast two-hybrid screens and mutational analyses. Two-hybrid screening … shoe station gulfport msWebDEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [ 3 ]. The structure of this domain shows it to be ... shoe station headquartersWebconserved DEK domain-containing protein is implicated in important chromatin-related processes in animals, but little is known about its DNA targets and protein interaction … shoe station grand openingWebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) shoe station hiking bootsWebJan 2, 2009 · The C-terminal region of DEK has a three helix bundle structure similar to that of winged-helix DNA-binding proteins such as DP2 (Devany et al. 2004 ). In this report, we describe the three-dimensional structure of the N-terminal region of DEK and its dsDNA-binding properties. Figure Figure 1. Open in figure viewer PowerPoint shoe station hokaWeb17 rows · Dec 24, 2014 · The evolutionarily conserved DEK domain-containing protein is implicated in important ... shoe station hattiesburg mississippiWebApr 30, 2015 · MBD2 also contains a C-terminal coiled coil (CC) domain that mediates protein–protein interactions and an N-terminal glycine-arginine (GR) repeat region that is subject to posttranslational … shoe station holiday hours