Global lipids genetics consortium results

Author: jauq

August undefined, 2024

WebDec 8, 2024 · In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood … WebNov 26, 2013 · Global Lipids Genetics Consortium Results. Reference. Willer CJ et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 2013. …

Relative effects of LDL-C on ischemic stroke and coronary disease

WebJul 14, 2016 · Given that several studies suggest an interdependence of cholesterol and vitamin D pathways in the pathogenesis of CAD, 55 we queried the association of rs12785878, in the largest publically available GWAS consortium results for lipids, the Global Lipids Genetics Consortium, 37 and found that this SNP was associated with a … WebGlobal Lipids Genetics Consortium. The Global Lipids Genetics Consortium is a worldwide collaboration of investigators dedicated to understanding the genetic etiology … four wheeler charger

JACC International - ScienceDirect

WebJul 26, 2024 · We selected genetic variants associated with lipid traits and related the summary effect sizes to those observed for CKD outcomes using the largest meta-analyses of GWAS to date: the Global Lipids Genetics … WebAug 8, 2024 · However, like many other genetic trait studies, large lipid meta-analyses, such as the Global Lipids Genetics Consortium ... There is a dearth of diversity of genetic studies that greatly impacts the ability to apply the results of genetic studies to non-European populations. With many biobank-sized resources only including European … WebGlobal Lipids Genetics Consortium Results Meta-Analysis Tables. The tables below summarize the results of the meta-analysis of variants genotyped using the exome array in 47,532 East Asian samples to test for association with HDL cholesterol, LDL cholesterol, total cholesterol and triglyceride levels. discount readers glasses

The power of genetic diversity in genome-wide association studies of lipids

Abstract 5223: Circulating lipoprotein lipids and ... - ResearchGate

WebOur results highlight the expected increase in variance explained by known loci when repeated lipid measurements are considered but also demonstrate the efficiency of … WebAug 17, 2024 · In some, but not all observational studies, higher TSH and lower FT4 are associated with unhealthier lipids and glucose metabolism, such as an association of higher TSH with higher total ... fourwheeler clutch baskethttp://csg.sph.umich.edu/willer/public/lipids2013/ discount ray ban wayfarer sunglasses

"WebJun 4, 2015 · Global Lipids Genetics Consortium. Data on the genetic association between the rs4299376 SNP and plasma lipid levels were obtained from a previously published genome-wide association study. ... Results of the National Cholesterol Education (NCEP) Program Evaluation ProjecT Utilizing Novel E-Technology … " - Global lipids genetics consortium results

Global lipids genetics consortium results

Homocysteine-reducing B vitamins and ischemic heart disease: a

WebMar 12, 2024 · Study populations. We obtained genome-wide association estimates for LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides from the Global Lipids Genetics Consortium (GLGC), based on up to 188,577 participants of European ancestry. 18 The effects of these genetic variants on CHD were examined in the … WebMar 2, 2024 · The Global Lipids Genetics Consortium (GLGC) study is a genome-wide genotyping analysis of 188,577 individuals to search for loci associated with plasma lipid levels . The aim of the FinnGen study is to research the national health registry data and genome of 500,000 Finns.

Did you know?

WebApr 4, 2024 · Abstract 5223: Circulating lipoprotein lipids and colorectal cancer risk: A Mendelian randomization analysis from the GECCO consortium April 2024 Cancer Research 83(7_Supplement):5223-5223 WebMar 11, 2024 · Leveraging data from the Global Lipids Genetics Consortium (n = 173 082), we identified genetic variants to proxy LDL-c levels generally, ... (n = 1 012 240) using Mendelian randomization, and replicated results using the outcome of longevity to the 90th vs. 60th percentile age (11 262 cases/25 483 controls). Results.

WebMar 21, 2024 · The latest GWAS from the Global Lipids Genetics Consortium (GLGC) reports 941 loci, ... This inequity results from a variety of reasons linked to historical national developments, scientific and ... WebApr 22, 2024 · Variants were robustly associated with LDL-C in a meta-analysis of genome-wide association studies (GWAS) involving 188,578 individuals primarily (96%) of European ancestry in the Global Lipids Genetic Consortium (GLGC) . As previously described by Ference et al., SNPs were iteratively selected for inclusion in order of decreasing …

WebJun 14, 2024 · New Results Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation. ... We obtained …

WebThe power of genetic diversity in genome-wide association studies of lipids Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied …

WebThe GLGC (Global Lipids Genetics Consortium) focused on the genetic etiology of quantitative lipid traits ... and field center data for generating results and alert reports for participants. Field center staff may either record data and validate them directly in the system or collect data first on paper forms and then key and validate them into ... discount ready made picture framesWebAug 8, 2024 · Lipid levels are a major risk factor for cardiovascular disease, the leading cause of death in the United States . While lipid levels are known to have a highly … discount reading glasses for menWebOct 1, 2024 · Summary-level data for 223 genome-wide lipids-associated variants were obtained from publicly available data from the Global Lipids Genetics Consortium 11. We then utilized results from a GWAS of 5,002 AAA cases and 139,968 controls performed in white MVP participants using the definition proposed by Denny et al 17. The effect alleles … discount reading eyeglasses onlineWebMar 29, 2024 · Shown are the multivariable MR (MVMR) results from the discovery analysis, using genetic instruments for plasma TG levels from Global Lipids Genetics Consortium (GLGC) and disease traits from UKB. Levels of statistical significance are categorized into three tiers: Tier 1 (BB): At least Bonferroni-significant in both the … discount real estate brokers in hawaiiWebthat can be considered as proxies for specific lipid-lowering medications. We obtained associations with lipid fractions from the Global Lipids Genetics Consortium, a meta … discount ray ban wayfarer polarizedWebApr 6, 2024 · Abstract. The risk of Alzheimer disease (AD) increases with age, family history and informative genetic variants. Sadly, there is still no cure or means of prevention. As in other complex diseases ... four wheeler colorado springshttp://csg.sph.umich.edu/willer/public/glgc-lipids2024/#:~:text=The%20Global%20Lipids%20Genetics%20Consortium%20aggregated%20GWAS%20results,N%3D48.1k%2C%202.9%25%29%2C%20and%20South%20Asian%20%28SAS%2C%20N%3D41.0k%2C%202.5%25%29. discount reading sunglasses