How does daptomycin cause myopathy

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August undefined, 2024

WebMar 7, 2024 · Cubicin may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose), … WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the …

Muscle pain associated with daptomycin - PubMed

WebJun 15, 2006 · Given the temporal relationship between daptomycin initiation and elevation in CPK level, daptomycin was identified as the offending agent and was discontinued. … WebDec 19, 2024 · In this retrospective, case-control study, both myopathy and rhabdomyolysis were increased by coadministration. Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. Although prior reports suggested no increased risk for myopathy when … on site vs off site

Daptomycin - Infectious Diseases - Merck Manuals Professional Edition

WebMitochondrial myopathy is caused by a defect in the mitochondria, which are the energy-producing part of cells. These conditions have muscle weakness, but also a variety of … WebMar 7, 2024 · dizziness, trouble sleeping (insomnia), anxiety, itching or skin rash, increased sweating, or. injection site reactions (pain, discomfort, irritation, redness, or swelling). Tell your doctor if you have serious side effects of Cubicin including: muscle pain/cramps/weakness, numbness or tingling of hands or feet, WebDaptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. It is usually given once a day. The length of your treatment depends on … iodine in white rice

Daptomycin Uses, Side Effects & Warnings - Drugs.com

Daptomycin (Intravenous Route) Before Using - Mayo Clinic

WebAn endocrine myopathy is a myopathy caused by issues with the endocrine system, which controls hormone production. Endocrine myopathies can be caused by thyroid or adrenal diseases. Infectious... WebDaptomycin. Daptomycin is a lipopeptide that targets bacterial cell membranes and has been successfully used to treat skin and soft tissue infections caused by Gram-positive bacteria, including E. faecalis species. ... The primary toxicity seen is a dose-dependent, reversible myopathy that can be monitored by elevation in serum creatinine ... onsite wastewater treatment plantWebMar 1, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry stools bladder pain bloody or cloudy urine blurred vision chest pain, discomfort, or tightness chills confusion cough decreased awareness or responsiveness on site water heater

"WebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) monitoring and temporary discontinuation of 3-hydroxy-3-methylglutaryl coenzyme A … " - How does daptomycin cause myopathy

How does daptomycin cause myopathy

WebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received daptomycin; however, there have been no previously reported cases of rhabdomyolysis in … WebDaptomycin. Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to the bacterial cell membranes, causing rapid depolarization of the …

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WebDoses more than 8 mg/kg IV every 24 hours increase the risk of CPK elevations and myopathy. Use clinical judgment and frequent monitoring if pursuing doses of 10 to 12 mg/kg IV every 24 hours in patients receiving an UFR of at least 3 L/hour. Pediatric patients†. 8 mg/kg/dose IV every 48 hours. Hybrid hemodialysis†. WebMar 21, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry …

WebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of International... WebFocal fibrosing myopathies: Due to injections of drugs Selumetinib Valproate Mitochondrial disorders (MELAS): Induces myopathy & encephalopathy CPT-2 deficiency: Precipitates …

WebWhile the statins are effective in providing protection from coronary and cardiovascular events, they are known to cause myopathy (usually dose-related) and, rarely, rhabdomyolysis. 1 A clinical diagnosis of myopathy is made when there is muscle pain or weakness accompanied by a creatine kinase (CK) level more than ten times the upper … WebMar 21, 2024 · Daptomycin may cause a kidney problem called tubulointerstitial nephritis. Check with your doctor right away if you have a bloody or cloudy urine, fever, skin rash, …

WebJan 28, 2024 · new or worsening cough , fever, trouble breathing, unexplained muscle pain, tenderness, and. weakness. Rare side effects of Daptomycin include: none. This is not a …

WebIn terms of adverse reactions, daptomycin is known to cause elevations in creatine kinase and myopathy, though this rarely leads to rhabdomyolysis, additionally, long-term use may cause allergic pneumonitis (Beauduy & Winston, 2024a; Macdougall, 2024b ). View chapter Purchase book Recommended publications Essentials of Neuroanesthesia Book • 2024 on site water filter water coolerWebJan 1, 2024 · Daptomycin for injection is indicated for the treatment of adult patients with Staphylococcus aureus bloodstream infections (bacteremia), including adult patients with right-sided infective endocarditis, caused by methicillin-susceptible and … iodine isotopes listWebFeb 28, 2024 · A drug-induced myopathy is defined as the manifestation of myopathic symptoms occurring in patients without prior muscle disease when exposed to certain … on site water jet cutting servicesWebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the most clinically relevant adverse effects of daptomycin is reversible myopathy, especially when daptomycin is used in high doses. iodine is obtained from laminariaWebNov 23, 2024 · Daptomycin must be mixed with a liquid (diluent) before using it. Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. You may need frequent blood and urine tests. daptomycin may cause false results with certain medical tests. iodine is a test forWebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. NOTE: This is the Professional Version. iodine is metal or nonmetalWeba disease with shrinking and weaker muscles called myopathy atrial fibrillation atrial flutter supraventricular arrhythmias, a type of abnormal heart rhythm pneumonia with high amount of... on site water purifier