Irf7 macrophage
WebFeb 26, 2024 · As reported previously 29, 30, 31, pro-inflammatory macrophage-inducing factor LPS or LPS + IFNγ significantly increased macrophage glycolytic pathway activity, while anti-inflammatory... WebOverexpression of IRF7 resulted in enhanced viral replication while knocking down IRF7 expression in macrophages significantly reduced viral output. These findings are the first demonstration that ...
Irf7 macrophage
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WebApr 21, 2024 · JEV infection resulted in M-MDSC infiltration into the CNS, and the infiltrated M-MDSCs later differentiated into CD3 + macrophages. RNA-seq data and in vitro experiments indicated that the ZBP1-IRF7 signaling pathway plays an important role in JEV-induced M-MDSC generation. WebIntact Type I Interferon Production and IRF7 Function in Sooty Mangabeys [PubMed: PMC3757038] PLoS Neglected Tropical Diseases: Innate Immune Response to Rift Valley Fever ... Infection of equine monocyte-derived macrophages with an attenuated equine infectious anemia virus (EIAV) strain induces a strong resistance to the infection by a ...
WebApr 14, 2011 · IRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and is potently... WebNov 1, 2024 · We performed single-cell RNA sequencing on 113,213 bronchoalveolar lavage cells from four healthy and three uninflamed cystic fibrosis subjects and identified two MARCKS+LGMN+IMs, FOLR2+SELENOP+ and SPP1+PLA2G7+ IMs, monocyte subtypes, DC1, DC2, migDCs, plasmacytoid DCs, lymphocytes, epithelial cells, and four AM …
WebOverexpression of IRF7 or miR-1587 knockdown reversed M2 macrophage-induced cell proliferation and migration as well as tumor growth in vivo. Mechanistically, miR-1587 … WebMar 9, 2024 · studies suggest that expression of the IFN-alpha/beta receptor on macrophages/neutrophils and dendritic cells, as well as of IRF-3 and IRF-7, is critical for innate immune responses to NoV infection IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells
WebJul 19, 2010 · Macrophages exposed to hypoxia accumulate both HIF-1α and HIF-2α, and overexpression of HIF-2α in tumor-associated macrophages (TAMs) is specifically correlated with high-grade human tumors and poor prognosis. However, the precise role of HIF-2α during macrophage-mediated inflammatory responses remains unclear.
WebAug 11, 2009 · TLRs that utilize MyD88 display defects in IFN-I production in cells lacking IRF7 . As macrophages and DCs express high basal levels of this critical transcription factor, this distinct signaling pathway contributes to their ability to be potent producers of IFN-I. Separate studies suggest NF-κB-inducing kinase (NIK) may also be a member of ... ina garten butternut squash farroWebNov 30, 2001 · Interferon regulatory factor 7 (IRF-7) is expressed predominantly in lymphoid tissues and has been studied extensively in the context of viral infection and the induction … ina garten buttermilk fried chicken recipeWebMar 29, 2024 · IRF5 is expressed predominantly in B cell, monocytes, macrophages and pDCs. Activation of IRF5 involves phosphorylation by IKKβ (36, 37) at conserved residues … ina garten butternut squash saffron risottoWebHere, we show that Lipofectamine induced type I IFN signaling in both RAW 264.7 macrophage-like cells and primary bone marrow-derived macrophages. Type I IFN induction was dependent on interferon regulatory factor (IRF)3 and IRF7 and partially required the toll/interleukin-1 receptor-domain-containing adapter-inducing interferon-β. ina garten brussel sprout recipeWebNov 30, 2001 · Interferon regulatory factor 7 (IRF-7) is expressed predominantly in lymphoid tissues and has been studied extensively in the context of viral infection and the induction … ina garten butternut squash hummus recipeWebSep 10, 2024 · SeV-induced IRF7 expression in macrophages was accompanied with two weak upshifted bands: one at around 60 kDa and another at the position similar to … in 1913 income tax was reinstated whyWebDec 26, 2024 · Furthermore, IRF7 contributed to M1 characteristics through the activation of SAPK/JNK pathway. Moreover, targeting IRF7-SAPK/JNK pathway to induce M1 characteristics in LAMs contributed to prolonged survival in leukemia mice. Our study provides the potential target for macrophage based immuno-therapy strategy against … ina garten buttermilk fried chicken