Sftpb protein function

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August undefined, 2024

SP-B plays a critical role in the functioning of healthy lungs, and its absence inevitably leads to lung conditions, most common of which being acute respiratory distress syndrome (ARDS). Because of this, SP-B's function has been well researched, and has been found to exist in three parts. Beyond these three functions, it is worth noting that SP-B is also thought to have some anti-inflammatory function, though it is not well defined. WebSurfactant protein dysfunction syndromes are highly variable in their onset and presentation, and are dependent on the genes involved and environmental factors. This heterogeneous …

SFTPB gene: MedlinePlus Genetics

Web20:Airway & Pancreas - Proteolysis41:Alveolar cells - Lung function63:Astrocytes - Nervous system maintenance62:B-cells - B-cell activation70:Basal prostatic cells - Lipid … Web20:Airway & Pancreas - Proteolysis41:Alveolar cells - Lung function63:Astrocytes - Nervous system maintenance62:B-cells - B-cell activation70:Basal prostatic cells - Lipid … co-organized by

Pro–Surfactant Protein B As a Biomarker for Lung Cancer Prediction

WebThe SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. … Web2 Oct 2024 · Surfactant proteins (SP) are involved in surfactant function and innate immunity in the human lung. Both lung function and innate immunity are altered in CF, and altered SP levels and genetic association are observed in Cystic Fibrosis (CF). We hypothesized that single nucleotide polymorphisms (SNPs) within the SP genes associate … Web22 Jan 2024 · This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. famous cardinals religion

Plasma pro-surfactant protein B and lung function decline in smokers

WebSFTPB, or pulmonary-associated surfactant protein B, is an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant-associated … Web22 Jan 2024 · This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. … famous cardiologists in usaWeb[9] SFTPB, together with other proteins and phospholipids, creates a barrier on the surface of the alveoli that prevents damage to the alveoli during breathing and is largely generated and secreted by type II cells[10]. The SFTPB gene has been linked to pulmonary illnesses and lung function in earlier research. co organic compound

"WebPlasma pro-surfactant protein B (pro-SFTPB) levels have recently been shown to predict the development of lung cancer in current and ex-smokers, but the ability of pro-SFTPB to predict measures of chronic obstructive pulmonary disease (COPD) severity is unknown. We evaluated the performance characte … " - Sftpb protein function

Sftpb protein function

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Web8 Feb 2024 · Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown. - Abstract - Europe PMC Europe PMC is an archive of life sciences journal literature. Europe PMC Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific … WebDescription. Surfactant dysfunction is a lung disorder that causes breathing problems. This condition results from abnormalities in the composition or function of surfactant, a …

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WebTransfection of A549 cells with NKX2-1 expression vectors demonstrated decreased stimulation of SFTPB and SFTPC expression by mutant proteins compared with that of WT. Conclusion: Disruption of transcriptional activation of surfactant protein genes by these DNA-binding domain mutations is a plausible biological mechanism for disruption of … WebSFTPB. CELL LINE. Human cell lines. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC.

WebNX_P07988 - SFTPB - Pulmonary surfactant-associated protein B - Function. Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. WebThe hydrophobic surfactant proteins B and C are essential for lung function and pulmonary homeostasis after birth. These proteins enhance the spreading, adsorption, and stability …

Web29 Mar 2024 · Summary This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis … WebNot analysed since only proteins predicted to be actively secreted to blood is analysed here Mass spectrometry i Detection or not of the gene in blood, based on spectral count …

Web18 Nov 2013 · Here, we report on the possible role of circulating pro–surfactant protein B (pro-SFTPB) as a biomarker for early detection of non–small-cell lung cancer (NSCLC). SFTPB is synthesized initially as a hydrophilic 42-kD protein by type 2 alveolar pneumocytes and nonciliated bronchiolar cells as pro-SFTPB.

WebPulmonary surfactant-associated protein B (SFTPB) is a critical protein for lung homeostasis, and polymorphism of its gene is associated with chronic obstructive … famous cardiologist in singaporeWeb26 Dec 2013 · The mature (and functional) form of surfactant protein B (SFTPB) is approximately 8 kDa in weight and is extremely hydrophobic , . The main function of SFTPB is to accelerate the formation of a surface active film composed of phospholipids at the air-water interface by increasing adsorption rate . co-organising coorg 2 days tripWebSFTPB. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. co organizer in gotomeetingWeb20:Airway & Pancreas - Proteolysis41:Alveolar cells - Lung function63:Astrocytes - Nervous system maintenance62:B-cells - B-cell activation70:Basal prostatic cells - Lipid metabolism35:Bipolar cells - Visual perception30:Breast - Lactation5:Bronchus - Unknown function77:Cardiomyocytes - Muscle contraction56:Ciliated cells - Cilium … coorg and chikmagalur packages from bangaloreWebSFTPB is an amphipathic surfactant protein critical for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which consist of plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. Pulmonary surfactant-associated proteins support alveolar stability by ... famous career criminalsWebThe SFTPB gene provides instructions for making a protein called surfactant protein-B (SP-B). This protein is one of four proteins (each produced from a different gene) in … coorg and madikeri