Staurosporine biosynthesis翻译

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August undefined, 2024

WebJul 24, 2001 · Staurosporine treatment led to rapid dissociation of eIF4G 1 from eIF4E, which became almost maximal at 2 h of treatment (the ratio of 4E/4G 1 from …

Staurosporine - PMC - National Center for Biotechnology Information

WebStaurosporine isolated from Streptomyces sp. TP-A0274 is a mem-ber of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in … WebAntiSMASH analysis identified 28 biosynthetic gene clusters (BGCs) from BV410-1, including that responsible for staurosporine biosynthesis, while 20 BGCs were identified from BV410-10. The ... kings hill golf scorecard

Metabolism Studies of Indole Derivatives Using a Staurosporine …

WebAmong the various examples of radical-mediated coupling and ring formations the biosynthesis of the glycosylated indolocarbazole staurosporine stands out for having three radical steps during ... Web苯丙烷代谢受到多种调节通路的调控，如转录调控、转录后调控、翻译后调控、表观遗传调控。此外植物激素、生物和非生物胁迫也会影响苯丙烷代谢。mbw三元复合体由r2r3-myb转录因子，bhlh转录因子以及wd40蛋白构成，参与调控花青素、原花青素及鞣酐的形成。 WebOct 1, 2024 · The sta BGC spanned 23.3 kb and encoded all essential genes required for the biosynthesis of staurosporine (Onaka et al., 2002). The organization of core genes in the Streptomyces sp. BV410‐1 sta cluster was identical to those found in other two streptomycetes, staurosporine producers that we used for comparison. kingshill infant school

Isolation and identification of Streptomyces sp. Act4Zk, a good ...

Cloning of the staurosporine biosynthetic gene cluster …

WebIn the biosynthesis of the antitumor indolocarbazoles rebeccamycin and staurosporine by streptomycetes, assembly of the aglycones involves a complex set of oxidative condensations. Overall formation of aglycones K252c and arcyriaflavin A from their biosynthetic precursor chromopyrrolic acid involves four- and eight-electron oxidations, … WebJan 1, 2005 · The staurosporine biosynthetic gene cluster in Streptomyces sp. TP-A0274 consists of 15 sta genes. In the cluster, it was predicted that staN , which shows high … kings hill lane coventryWebJan 17, 2024 · Staurosporine-related structures have been derivatized and developed into selective inhibitors of pharmacologically interesting targets [PMID: 19132059]. About This Pathway The first enzyme in staurosporine biosynthesis to be identified was the one catalyzing the very last step (MONOMER-15145). kings hill medical imaging

"WebDec 29, 2004 · Studies on the biosynthesis of rebeccamycin and staurosporine in the producing microorganisms have shown that the indolocarbazole core is formed by decarboxylative fusion of two tryptophan-derived units, whereas the sugar moiety is derived from glucose (8, 9).Recently, we cloned and characterized the rebeccamycin biosynthetic … " - Staurosporine biosynthesis翻译

Staurosporine biosynthesis翻译

Combinatorial biosynthesis of antitumor indolocarbazole compounds - PNAS

Webcarbazole; staurosporine; biosynthesis Staurosporine is an indolocarbazole compound pro-duced by certain actinomycetes strains.1,2) It and its derivatives are potent inhibitors of protein kinase C (PKC). The PKC family plays a key role in cellular signal transduction and is a promising target for antitumor compounds. Some indolocarbazole deriva- WebStaurosporine biosynthesis星形孢菌素的生物合成0040500405. Phenazine biosynthesis吩嗪生物合成. 0033300333. Prodigiosin biosynthesis Prodigiosin生物合成0025400254. …

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WebStaurosporine (1a), an indolocarbazole-based natural product, is a prototypical ATP-competitive kinase inhibitor with a high affinity against a broad range of kinases, … WebJul 1, 2013 · In staurosporine-treated cells, K-Ras is translocated to the ER, early endosomes, late endosomes/lysosomes and mitochondria, while H-Ras is redistributed …

WebOct 1, 1999 · (~ TETRAHEDRON LETTERS Pergamon Tetrahedron Letters 40 (1999) 7171-7174 Holyrines A and B, possible intermediates in staurosporine biosynthesis produced in culture by a marine actinomycete obtained from the North Atlantic Ocean David E. Williams,a Valerie S. Beman,b'* Frank V. Ritacco,b William M. Maiese,u Michael Greenstein b and … WebJan 17, 2024 · Staurosporine-related structures have been derivatized and developed into selective inhibitors of pharmacologically interesting targets [PMID: 19132059]. About This …

Webisomerase是英语词语可翻译为“异构酶”它是一种酶类分子能够催化同一分子的异构反应将一种分子转化为具有相同原子组成但分子结构不同的异构体分子，isomerase是什么意思 isomerase的读音、翻译、用法 ... Isomerase enzymes are involved in the biosynthesis of many important ... WebJan 9, 2009 · In staurosporine biosynthesis, staO initiates synthesis by catalyzing L-tryptophan to the imine form of indole-3-pyruvic acid (IPA imine) and staD, and then catalyzes the coupling of two IPA ...

WebStaurosporine（星形孢菌素，STS）是一种强效的、ATP竞争性激酶抑制剂，有效抑制PKC活性，在大鼠脑组织实验中，IC50为2.7 nM。Staurosporine强效抑制PKC-α，其抑制活性比PKC-δ高100倍，比PKC-δ和PKC-ζ高1000倍。除此之外，Staurosporine还抑制PKA，PKG，p60v-src酪氨酸蛋白激酶和钙调蛋白激酶II等。

WebCloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans. Journal J Antibiot (Tokyo) 55:1063-71 (2002) kings hill medical centrehttp://www.doczj.com/doc/5b15975076.html lvl lashes price listWebStaurosporine is a representative member of indolocarbazole antibiotics. The entire staurosporine biosynthetic and regulatory gene cluster spanning 20-kb was cloned from … lvl lash lift price averageWebMar 30, 2024 · 1.10 Biosynthesis of other secondary metabolites. 00940 M Phenylpropanoid biosynthesis 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis 00941 M Flavonoid biosynthesis 00944 ... Staurosporine biosynthesis 00405 M Phenazine biosynthesis 00333 M Prodigiosin biosynthesis 00254 M lvl lash glueWebNational Center for Biotechnology Information kings hill golf club restaurantWebStaurosporine, belonging to indolocarbazole compounds, is regarded as an excellent lead compound for synthesizing antitumor agents as a potent inhibitor against various protein … lvl lashes cartoonWebAt the Edge of Innovation. Where chemistry meets biology, products meet services and innovation meets quality, Biosynth secures life science supply chains with manufacture … kings hill golf course kent